Low-Dose Clonazepam Effect on Epileptiform Activity

Effect of curcumin, the active constituent of turmeric, on penicillin-induced epileptiform activity in rats

Objective: Curcumin is a major constituent of turmeric and has many biological functions such as anticancer and anti-inflammatory effects. The present study was conducted to investigate the effects of curcumin and diazepam in separate and combined treatments on penicillin-induced seizures in rats. Materials and Methods: In urethane-anesthetized rats, epileptiform activity was induced by intrac...

Low-Calcium Epileptiform Activity in the Hippocampus In Vivo

Feng, Zhouyan and Dominique M. Durand. Low-calcium epileptiform activity in the hippocampus in vivo. J Neurophysiol 90: 2253–2260, 2003; 10.1152/jn.00241.2003. It has been clearly established that nonsynaptic interactions are sufficient for generating epileptiform activity in brain slices. However, it is not known whether this type of epilepsy model can be generated in vivo. In this paper we in...

A unique effect of clonazepam on frontal lobe seizure control

In a 16-year-old female, clonazepam (CZP) changed randomly occurring intractable tonic seizures of frontal lobe origin to a few sleep seizures when used as an adjunctive therapy. The significance of this change in the seizure pattern is discussed with an explanation of possible pathophysiologic mechanism.

Effect of enteric coating on antiplatelet activity of low-dose aspirin in healthy volunteers.

BACKGROUND AND PURPOSE Aspirin resistance may be relatively common and associated with adverse outcome. Meta-analysis has clearly shown that 75 mg plain aspirin is the lowest effective dose; however, it is not known whether the recent increased use of enteric-coated aspirin could account for aspirin resistance. This study was designed to determine whether enteric-coated aspirin is as effective ...

Wireless Sensing of Epileptiform Activity